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KMID : 1134820000290020235
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Journal of the Korean Society of Food Science and Nutrition
2000 Volume.29 No. 2 p.235 ~ p.240
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Physiological Effects and Utilization of Corbicula elatior Products - Effect of Cockle Extracts on Carcinogen - induced Cytotoxicity and Immune Response Related to Its Antitumor Activity -
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Suh Jae-Soo
Jang Myung-Woong
Chun Soon-Sil
Choi Myung-Won
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Abstract
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Inhibitory effects of cockle extracts on carcinogen-induced cytotoxicity in C3H/10T1/2 cells were studied. Soup (62 μg/mL), solubility (28 μg/mL) and liposolubility (9 μg/mL) of the cockle inhibited 3-methyl- cholanthrene (MCA)-induced cytotoxicity in C3H/10T1/2 cells by 53 and 94%, respectively. These results suggest that the extracts cockle might have anticarcinogen-induced cytotoxicity of C3H/10T1/2 cells. The effects of cockle extracts on the immune response related to its antitumor activity in vitro and in vivo were investigated. The cockle extracts showed a direct cytotoxic effect on sarcoma-180 cells, tumor cells in vitro. Soup (0.49 mg/mL), solubility (0.11 mg/mL) and liposolubility (0.05 mg/mL) of the cockle markedly decreased the total numbers of sarcoma-180 cells, but not their viability. The phagocytic activity of peritoneal macrophage of mice was significantly augmented by these extracts of the cockle compared with that of control in vivo. These extracts also raised the phagocytic index, indicating that the number of phagocytized microbes per macrophage increased. Thus, cockle extracts might show a antitumor activity by enhancing the phagocytic cell activities.
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KEYWORD
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cockle, C3H/10T1/2 cells, cytotoxicity, antitumor effects
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